Background: Studies have suggested a tight linear correlation between the SUA and SBP, DBPin children with pre-hypertension. Many factors, including family history, genetics, insulin resistance and BMI, play a role in the development of essential hypertension. Aims and Objectives: 1) To assess the SUA, BPin offspring’s of patients with essential hypertension (cases), and in age and sex matched healthy controls. 2) To compare and thereby to test the hypothesis that a “significant correlation is present between the SUA and BP”. Methodology: Thirty cases and thirty controls without history of essential hypertension in the family were randomly selected. Out of thirty subjects in each group, ten females and twenty were males aged between 17-25years.SUA, blood urea, serum creatinine, triglycerides, total cholesterol, FBS and BP were measured in both groups along with anthropometric measurements viz., height, weight, BMI, waist- hip ratio. Data was tabulated and statistically analysed using SPSS software. Results and Conclusions: It was found that both groups were well matched with respect to age, sex, BMI, and waist-hip ratio. The two groups also did not differ much in their lipid parameters, renal parameters, FBS (except serum creatinine). BP (systolic and diastolic, p<0.001, p=0.075) was significantly higher in cases in comparison to controls. Further analysis did not reveal any positive correlation between SUA and SBP in cases(r=-0.265, p=0.157). So it was concluded that the correlation between SUA and SBP has been distorted in cases due to confounding factors like age, etc.

Keywords: BP; Essential hypertension; SUA.