The purpose of this study was to determine the effectiveness of topically applied minoxidil in the pharmacological delay phenomenon. There are various types of delay including surgical delay, pharmacological delay. We have used topical minoxidil application on latissimusdorsi flap reconstruction for a patient who had undergone neoadjuvant chemoradiation. We have found that topical minoxidil can be used to prevent flap necrosis in such conditions.