Necrotizing fasciitis is an infection of subcutaneous tissue and fascia which may spread rapidly to deeper tissue and surrounding tissue which may cause damage to the tissue and present as a localized infection and fulminant septic shock with high mortality rate. Necrotizing fasciitis will undergo extensive wound debridement of the necrotic tissue which may create huge raw area with severe morbidity to the patient. A multidisciplinary team has successfully adopted advanced reconstructive methods combined with modalities from regenerative medicine to enhance the results of difficult reconstruction. These procedures, known as "Hybrid reconstruction ladder," combine conventional reconstruction techniques with regenerative medicine applications. This review article provides a summary of the benefits of using a hybrid reconstruction ladder to create a healthy wound bed and reconstruction in a case of necrotizing fascitis