Skin substitutes are a heterogeneous group of biologic, synthetic, or biosynthetic materials that can provide coverage of open skin wounds. The aim of skin substitutes is to replicate the properties of the normal skin. Biocompatibility, antimicrobial activity, appropriate hydrophilicity, and biodegradability are all desirable qualities in a skin substitute. The goal of tissue engineering research is to develop cell-based wound substitutes or wound covers that promote cell migration, differentiation, and vascularization to facilitate wound healing.