Premenstrual syndrome (PMS) as associated with cyclical symptoms occurring in second half of menstrual cycle (lutealphase). Non-pharmacological management include high protein diet,regular exercise, stress reduction. Adolescent girls with PMS have been treated with gamma linolenic acid, an essential fatty acid precursor of prostaglandin E1. Vitamin B6 (pyridoxine) up 100 milligrams per day is helpful. Nutritional supplements like calcium, magnesium and chromium play a vital role in management of PMS. Non-hormonal therapy for PMS include: Anti-inflammatory drugs, diuretics, anxiolytics and selective serotonin reuptake inhibitors (SSRI). Hormonal therapy recommended for PMS is progesterone in luteal phase, low dose combined OC pills and GnRH.

Keywords: Premenstrual Syndrome; Pyridoxine; Nutritional Supplements; Progesterone.