Introduction: It has now become apparent that the majority of hospitalacquired hyponatremia in children is iatrogenic and due in large part to the administration of hypotonic fluids to patients with elevated Arginine vasopressin levels (AVP). The practice of administering hypotonic parental fluids was established over 50 years ago, before recognition of the fact that there are numerous potential stimuli for AVP production in most hospitalized patients.

Methodology: Hospitalized children who fulfilled inclusion criteria and not having any of the exclusion criteria were considered for the enrolment after written informed consent. Venous blood samples were taken at enrolment for estimation of serum sodium, potassium, chloride, blood sugar, blood urea, serum creatinine.

Results: The incidence of hyponatremia in group B was highly significant 25% (p value 0.006) in comparison with group A (RL) which was only 6.66% and was not significant. The incidence of hyponatremia in group B was highly significant 30% (p value 0.049) in comparison with group A (RL) which was only 15% and was not significant.

Conclusion: There is significant increase in the hospital stay in hyponatremic patients more so in group B.

Keywords: Hyponatremia; Multiple Electrolytes; Maintenance Therapy.