Hemophagocytic lymphohistiocytosis (HLH), is a rare, fatal condition characterised by  excessive activation of lymphocytes and macrophages due to a highly stimulated but ineffective immune process. We report a case of secondary Hemophagocytic Lymphohistiocytosis in a 13 year old boy presenting with fever, splenomagaly  and bicytopenia due to infection caused by P.falciparum.