Adolescence is a transitional journey from childhood to adult life along with physical development and sexual maturation. This may be considered as physical, psychological and emotional rebirth. HPV is the cause of variety of proliferative lesions in humans including anogenital warts and neoplasia. Immunization is one of the most important, most beneficial and cost effective disease prevention measures that can be provided for adolescents. Bivalent and quadrivalent vaccines are available. The development of HPV vaccines is a major medical achievement of 21st century. Finally, there is hope that cervical cancer may be controlled globally. Keywords: Adolescent, vaccine, cervical cancer, HPV, prevention.