Epinephrine is the recommended agent for the medical treatment of all forms of cardiac arrest according to the European Resuscitation Council and American Heart Association guidelines. The same guidelines also permit the use of vasopressin as an alternate to epinephrine in cardiac arrest. In this issue we have tried to focus on the literature available on the use of vasopressin in cardiac arrest, and its advantages, if any, when used in lieu of or simultaneously with epinephrine.

Keywords: Cardiac arrest, epinephrine, vasopressin, return of spontaneous circulation.