RNA profiling or more specifically messenger RNA (mRNA) profiling is a very useful method to study the body fluids. Various type of body fluids can be found from a crime scene. Because of the changes in the fluids over period of time, it requires more improvise identification method. To study the different biomarkers in different body fluids which is not distinguishable in general process or to analyse the body fluids present in back spatter of a gun, RNA typing or profiling is a safe process. The difference between menstrual blood and peripheral blood, nasal mucosa and vaginal mucosa can be very important in a case. Most of cases DNA profiling for those body fluids are sensitive than RNA profiling. Results of those process show false positive results more which affect the case progress. RNA profiling helps to establish the correlation between DNA profiling in those cases. Addition of many pre mRNAs form a circular RNA (cRNA) which plays the most important role in RNA profiling.

Keywords: Difference between Body Fluids; RNA Profiling; More Accurate Results; Microrna; Forensic Serology.