At diagnosis approximately 45% of renal cell carcinoma presents with localized disease, 25% with locally advanced disease and 20-30% with metastatic disease. Mostly these tumors metastasize to lung, soft tissue, bone, liver and brain. Vagina is very unusal site of metastasis from RCC. The aim of presenting this case is the rarity of this type of presentation and to give emphasis that targeted therapy provides an extended survival along with improving quality of life of patient. 

Keywords: Renal Cell Carcinoma, Vaginal Metastasis, Targeted Therapy