Background: The incidence of mucositis is increased by adding concurrent chemotherapy as well as by altered fractionation radiation. The main aim of the study is to compare the efficiency of magic mouth wash and benzydamine mouth wash in prophylaxis and treatment of radiation induced oral mucositis in patients with head and neck cancers. 

Materials and Methods: The present randomized, comparative study conducted at Department of Radiotherapy at Guru GobindSingh Medical College and hospital a period between April 2016­June 2016. A total of 60 patients with head and neck cancer being treated with 6 or more weeks of radiotherapy to a total dose of 66Gy, 200cGy per day, 5 days a week,with shrinking field technique using 2D conventional method on cobalt teletherapy machine were randomly assigned to receive either the magic mouthwash (group A) or benzydamine (Group B) with equal number of patients i.e 30 patients in each group. All the results obtained were arranged in a tabulated form and analysed using SPSS software. 

Results: In the present study, the distribution of patients according to age was comparable in both groups. The mean age was 57.033 ± 12.397 in group A and 54.633 ± 11.418. There was no development of severe mucositis (grade 3­4) until week 3rd of treatment in both the groups. 4 patients (13.3%) in group B developed grade 3­4 mucositis in 4rth week. In the 5th week 1 patient  (3.33%) in group A and 6 patients (20%) in group B developed grade 3­4 mucositis. In the 6th and the 7th week 3 patients (10%) in arm A and 6 patients (20%)
in arm B developed severe reactions in each of these weeks respectively. 

Conclusion: From the above study, we can conclude that mouthwashes are an effective alternative for managing cases of mucositis, with magic mouth wash giving better results but there was no significant difference between both the groups.

Keywords: Magic Mouthwash; Benzydamine; Mucositis