GIST was introduced as a diagnostic term in 1983. GIST are only 0.2% of all GI tumors, the most common sarcoma of the gastrointestinal tract. GIST are thought to arise from the interstitial cells of Cajal (ICC), which are components of the intestinal autonomic nervous system acting as pacemakers regulating intestinal peristalsis. Jejunal GIST is rare and Pre-operative diagnosis is difficult. Diagnosis is confirmed on histopathology and immunohistochemistry.Complete removal with postoperative Imatinib therapy entails optimal treatment. We present a rare case of Jejunal GIST presented with obscure GI bleeding and managed successfully by surgery.  

Keywords: GIST- Gastro Intestinal Stomal Tumour; Malaena; Interstitial cells of Cajal.