AbstractIntroduction: Over 70% patients with cancer cervix present in advanced stages of the disease with coexisting urological complications like obstructed uropathy. Objectives: To determine the clinical profile of patients with urinary complications of advanced cancer cervix and the clinical outcome of the various therapeutic options administered. Material and Methods: In this study, 93 patients with advanced cancer cervix previously treated or untreated, who had obstructed uropathy were evaluated to know the type of urological complications, their management and their effect on the primary disease. Various methods of urinary reconstruction were tried and the clinical outcomes of these approaches were retrospectively analyzed. Results: A total of 93 patients included in the study, 37 (39.78%) were uraemic at presentation, majority of them being in stage II B of carcinoma cervix with 59 cases (63.44%) having bilateral obstruction. Of the 93 patients, 51 (54.83%) underwent surgical urinary diversion. Stenting was done in 86 (86.02%) cases, 15 (29.14%) had percutaneous nephrostomy, ileal conduit in 20 (39.21%), ureterosigmoidostomy in 8 (15.68%) cases, 8 patients had pelvic exenteration. 11 patients (11.82%) died before intervention. Outcome following urinary diversion procedure was poor, with 30 (58.82%) showing no clinical improvement. Complications following diversion procedures were detected late and were troublesome. Conclusion: Advanced cancer of the cervix leads on to obstructive uropathy, presenting as uraemia. Various urinary diversion procedures are useful in improving renal function, followed by definitive treatment options. At times they serve as life saving procedures.
Keywords: Obstructive uropathy; Advanced cancer cervix; Urinary diversion.