Introduction: Flupirtine is non-opioid, non-NSAID, centrally acting indirect NMDA receptor antagonist. It's analgesic effect is equivalent to NSAIDs and opioids with devoid of their side effects. Abdominal surgeries are the most painful surgeries amongst the surgical procedures. Aim: To evaluate the pre-emptive analgesic effect of flupirtine for postoperative pain relief in patients undergoing abdominal surgeries. Methods: 60 patients of either sex posted for elective abdominal surgeries were included in this study. These patients were aged between 18 and 60 years with ASA physical status I and II. They were randomly divided into two groups, named group A and group B. Patients in group A received 2 oral placebo capsules and group B patients received 2 flupirtine 100 mg capsules orally. Both drugs were administered two hours before the surgery. All patients underwent abdominal surgeries under general anesthesia. In the postoperative period patients were assessed for the intensity of pain using Numerical rating scale, Time to first rescue analgesia, Ramsay sedation score and side effects in the first 24 hours postoperative period. If NRS score ≥ 4, rescue analgesic tramadol 50 mg iv was given at 6 hours interval. Results: The mean NRS score was significantly decreased (p = 0.00) in group B patients for the first 3 hours. The time to first rescue analgesia was significantly high (p = 0.00) in group B patients. 60% of patients in group A received rescue analgesia in the first hour of the postoperative period. The mean RSS score was high in group B patients in the first 3 to 5 hours. The side effects were less in both groups. Conclusion: This study concludes that pre-emptive administration of oral flupirtine 200 mg provides effective analgesia in the first 2 to 3 hours of the postoperative period in patients undergoing abdominal surgeries with mild to moderate sedation.