Background: Relief of pain during operation is one of the mainstay of balanced anesthesia. So, any experience acquired in this field should be extended to the postoperative period also which could be done by use of suitable anesthesia. Objectives: To compare the effects of Clonidine and Low Dose Dexmedetomidine along with Bupivacaine on Pulse Rate, Blood Pressure and Respiratory Rate.). Materials and Methods: A Comparative study was carried out by the Department of Anesthesiology, G.R. Medical College and J.A. Group of Hospitals, Gwalior (M.P.). The study was done on 120 patients of ASA grade I & II of either sex with age group 18­60 years scheduled for elective lower limb surgeries. 40 Patients were allocated into different groups by randomization technique. Results: The demographic data of the three groups was comparable and the differences were not statistically significant (p>0.05).There was no statistically significant difference of (mean±SD) of Pulse Rate, Blood Pressure and Respiratory rate at different time intervals between three groups. Conclusion: We conclude that either, Intrathecal administration of clonidine (30µg) or dexmedetomidine (5µg) with hyperbaric bupivacaine 0.5% resulted without producing significant Hemodynamic or Respiratory Complication either during the time or surgery or post­surgery. Moreover, dexmedetomidine did not offer significant advantage over clonidine.