Background: Anaesthesia in dilatation and curettage (D & C) is administered with the dual goals of rapidly and safety establishing satisfactory procedural condition for the performance of therapeutic or diagnostic procedures while ensuring rapid predictable recovery with minimal post operative sequel.Therefore, we decided to use  Dexmedetomidine in 2 doses (1µg/ kg and 0.6µg/kg) with Ketamine (1 mg/kg) to provide procedural sedation in D&C and compare the efficacy and safety of dexmedetomidine 1µg/kg + 1mg/kg ketamine versus dexmedetomidine 0.6µg/kg + 1mg/kg ketamine for the procedure.

Material & Methods: This prospective randomized double blind study was conducted in department of Anaesthesiology of a Tertiary care hospital. In this study 80 patients scheduled for elective Dilatation and Curettage were included and divided equally in two groups.Group A- In this group 1µg/kg lnj. Dexmedetomidine was given, along with 1mg/kg lnj. ketamine IV and group B- Inthis group 0.6µg/kg lnj. Dexmedetomidine was given, along with 1mg/kg lnj. Ketamine IV.

Results: In our studythe mean age of patients in group A (41.5007 years) and group B (4 1.1008 years) differed insignificantly with p-value of 0.8254. The comparison of mean between two groups after giving dexmedetomedine was statistically significant in heart rate, DBP and SBP but respiratory rate & SpO2 was statistically not significant.

Conclusion: We have concluded that the comparison of baseline, intraoperative (after Ketamine) and post operative values of heart rate, systolic BP and diastolic BP showed that the values were better maintained in group A as compared to group B. Hence both the combination were comparable in safety but since the vital parameters were better maintained in group A, 1 µg/kg Dexmedetomidine + 1 mg/ kg Ketamine is better than 0.6 µ/kg.