Background: The first focus on haemodynamic response to laryngoscopy and tracheal intubation was done in 1950 by Burstein. King et al in (1951) described the abnormal circulatory reaction to laryngoscopy. Its association with a rise in blood pressure, tachycardia and increased level of catecholamines was highlighted by PrysRoberts in (1971) and by Siedlecki in 1975. Recognizing the hazardous effect of such reflex reactions, many techniques were studied and clinically tried to obtund these reactions. At the same time, The first publication on diagnostic laparoscopy by Raoul Palmer appeared in the early 1950s, followed by the publication of Frangenheim and Semm. Hans Lindermann and Kurt Semmpractised CO2 hysteroscopy during the mid1970s. However this procedure is not risk free, In fact it produces significant changes in haemodynamically compromised patients.The hallmark of laparoscopy is creation of carbon dioxide pneumoperitonium and change in the patients position from trendelenburg to reverse trendelenburg. It also results in stress hormone responses (cortisol, epinephrine and non–epinephrine) especially when CO2 pneumoperitonium is used concomitantly. Laryngoscopy with or without tracheal intubation amounts to a highly noxious stimulus to the homeostasis of the patient.

Aims: Designed to assess the effect of oral Clonidine premedication on hemodynamic response to endotracheal intubation and to compare intraoperative haemodynamic parameters, pain and sedation scores, time of first postoperative analgesia and dverse effects

Material and Method: Total 60 patients ASA grade I and II in the age group 20 to 55 years were included in this study and they were randomly divided into two groups:

Group 1 (n=30), patient received oral clonidine 150 mcg orally 90 min before induction

Group 2 (n=30), patients received oral vitamin C 100 mg orally 90 min before induction

All patients were posted for elective surgeries and were randomly selected.

Conclusion: The basal and perioperative arterial blood pressure and heart rate after giving premedication was lower in clonidine group as compared to placebo group. Time for 1st postoperative analgesia requirement in clonidine group was significantly prolonged in comparison with the ranitidine group.