Aim and Objectives: 1. to evaluate the effects of dexmedetomidine and clonidine on haemodynamic changes during Laryngoscopy and tracheal intubation. 2. To compare the effect of dexmedetomidine and clonidine on haemodynamic changes during Laryngoscopy and tracheal intubation. 3. To compare the side effects. 

Materials & Methods: After approval of the institutional ethical committee, this prospective observational study was conducted on 60 patients of ASA Grade I & II, undergoing elective surgeries under general anesthesia. 

Group A: Injection Dexmedetomidine 1mcg/kg diluted to 20ml with normal saline were given over 10 minutes.

Group B: Injection. Clonidine 2mcg/kg diluted to 20ml with normal saline were given over 10 minutes. 

All patients received Injection Pentazocine 0.3mg/kg and were preoxygenated for 3minute Anaesthesia was induced with thiopantone sodium (5mg/kg intravenous) till loss of eyelashreflex over 30 second and mask ventilation was confirmed. Injection succhinylcholine 1.5mg/kg was given to facilitate laryngoscopy and intubation. anaesthesia was maintained with oxygen nitrous oxide, halothane with intermittent use of injection Atracurium and controlled ventilation. At the end of surgery the neuromuscular blockade was antagonized with injection Glycopyrolate (.01mg/kg) Intavenou. And injection Neostigmine (.05mg/kg) i.v. and patient were extubated.

Result: Dexmedetomidine is more effective than Clonidine in attenuation of haemodynamic changes during laryngoscopy and intubation.

Conclusion: Dexmedetomidine significantly attenuates the haemodynamic changes during laryngoscopy and intubation. Clonidine also significantly attenuates the haemodynamic changes during laryngoscopy and intubation.Thus we conclude that Dexmedetomidine is a better drug to attenuate the haemodynamic response during laryngoscopy and intubation.