Background and Objective: The clinical study was undertaken to evaluate the efficacy of Thiopentone & Etomidate with reference to time to loss of eyelash reflex, hemodynamic parameters, pain on injection, myoclonus & other side effects if any. Material and Method: Study was conducted on 60 patients (according to Solvin’s formula) of either gender, ASA I & II, 20- 60 years old, posted for elective surgeries for general surgery and Ear Nose and Throat surgery. All the patients were premedicated with inj. Fentanyl 2 mcg/kg iv slowly along with other pre medicating drugs and divided into 2 groups. Group E induced with inj. Etomidate 0.3 mg/kg iv and the group T induced with inj. Thiopentone 5 mg/kg iv. The induction time was calculated from the start of injection to the loss of eyelash reflex. The patient’s hemodynamic changes during baseline, at the time of induction and 1 min, 2 mins, 5 mins & 10 mins after the induction were recorded. Pain on injectionand myoclonus were recorded during induction and other side effects were noted. Results: Induction time was faster in Group E (23.23±5.2 seconds) when compared with group T (32.60±4.5 seconds) (p value<0.05). Hemodynamic changes were more stable in group E and Pain on injection and Myoclonus were observed only in group E (8 & 10 patients respectively). Conclusion: Etomidate causes good hemodynamic stability with rapid induction than Thiopentone.