Background and Aim: To compare the application of betamethasone gel, lignocaine gel and KY jelly on the endotracheal tube to reduce the incidence of postoperative sore throat, cough and hoarseness of voice. Materials and Methods: With a formalapproval of our institutional ethical committee 135 patients scheduled for elective surgeries were chosen for this double blinded controlled study. They were randomized into three groups after their informed consent as betamethasone gel (Group A), lignocaine gel (Group B) and KY jelly (Group C). Postoperatively patients were quizzed about their sore throat, cough and hoarseness of voice and for any airway complications. Observation and Results: The age group of the patients in our study was between 18 and 65 years with mean age of 35.1±12.7 yrs in betamethasone group (A), 41.1±14.4 yrs in lignocaine group (B) and 39.6±15 yrs in KY jelly group (C). The incidence of sore throat was 35.6%, 71.2% and 64.4% in one hour and 31.1%, 71.2% and 60% in 24 hours for group A, B and C, respectively which was lowest in betamethasone group (A).The incidence of cough in our study was 31%,29% and 46 % in first hour and 20%,20% and 4.4% in 24 hour for group A, B & C, respectively. There were no complaints of severe cough in all 3 groups.The incidence of hoarseness of voice was found to be 34%, 40% and 22% in first hour and 7%, 38.8% and 42% in 24 hour for group A, B & C, respectively. There were no statistically significant difference noted between groups (p >0.05). Conclusion: Though postoperative cough and hoarseness of voice was present in all the groups but the severity of cough and hoarseness of voice was less in betamethasone group.