Ankylosing Spondylitis is an autoimmune seronegative spondyloarthropathy which manifests as a relapsing remitting disease. Since the disease involves the spine, it becomes significant for anesthesiologists as ensuring airway control in general anesthesia, and regional neuraxial blockade becomes difficult. Hence the anesthesiologist should be prepared beforehand with the anesthesia plan and the backup plan if the primary plan fails. In this report, we highlight the anesthetic management of a 66 year-old male who was a known case of ankylosing spondylitis and was planned for a total hip replacement.