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Abstract

Introduction: Depression and diabetes are both chronic devastating conditions & their co-occurrence has been associated with poor outcomes. The link between depression and type 2 diabetes is bidirectional, significant candidate pathways include the innate inflammatory response, the hypothalamic[1]pituitary-adrenal (HPA) axis, and insulin resistance, which all interrelate with each other. In formerly undiagnosed diabetic patients, depression had a higher prevalence and might be due to an unfavorable or stressful lifestyle such as condensed physical activity, socioeconomic scarcity, social adversity, unhealthy diet. In this study, the emphasis was made on screening for depression in patients with T2DM. Aim of the study: To investigate the incidence of Depression in Patients with T2DM. Objectives of the study: To obtain demographic details, to assess the depression levels, and to establish the relation based on the severity of depression in T2DM patients. Methodology: It is a prospective observational study design, the patient health questionnaire (PHQ[1]9) was used to assess depression in 387 patients aged between 30-80 years. Venous blood was collected to assess fasting blood sugar (FBS), post-lunch blood sugar (PLBS) and Glycated hemoglobin (HbA1c). Results: The PHQ-9 revealed that 182 patients (47%) are minimal in depression severity followed by 169 patients (38.5%) are mild in depression severity. Female gender, increased age, obese patients, and longer duration of diabetes was associated with increased odds of depression. Whereas, being married was protective and was associated with decreased odds of depression. Conclusion: In our study, we found the majority of subjects with minimal severity of depression when correlated between depression and T2DM. When HbA1c levels are compared, patients with higher levels of HbA1c are presented by subjects with moderate levels of depression. 

Keywords : Type 2 Diabetes mellitus; HbA1c; Depression; Patient health questionnaire-9; Depression severity

Corresponding Author : B.S. Sharavana bhava, Department of Clinical Pharmacy and Pharm D, Vaagdevi College of Pharmacy, MGM Hospital, Kakatiya University, Warangal, Telangana 506009, India. sharavanabhava6@gmail.com