The pineal gland was remained and unexplained inexplicable and the last of the endocrine gland to be discovered by the scientists, hence long considered odd and mystifying. Still it is not fully understood as some underground secret of the pineal gland is still a bit of mystery and yet to be clear. Although medical science has immeasurably progressed, even then there are a few things and some mysterious facts about this critical organ the pineal gland we might not have known. The evidence from the structural and developmental biology suggests that pinealocytes possess a common evolutionary predecessor with the retinal cells. It collects information related to light through the eye and then the melatonin produced by the pineal gland directs hormonal messages to the various parts of the body. The pineal gland is recognized today as performing a great part in controlling all aspect of human functions as the regulator of regulators. It establishes our sleep-wake cycles and regulates the major physical processes like growth, metabolism and sexual development by releasing and controlling the hormones. Apart from its documented special effects on reproductive system, body growth, body temperature, blood pressure, motor activity, sleep, tumor growth, mood and the immune system, it also seems to be a definitive factor in longevity. The calcified pineal gland by disturbing the circadian rhythm affects the nature and the quality of the sleep; reduces mental performance, sexuality and cognitive functioning; and finally makes the body prone to disease and disturbed overall personality. Decalcification of the pineal gland is an imperative part of our awakening and development; as doing so intensifies our perception and awareness of realism and for higher mental performance. Also it is very important and necessary for all the achievers interested in a state of mastery and blissful life; and seeking to be converted into more evolved humans.