Background: In a hospital, hazardous substances such as body fluids, drugs, cleaning fluids and other chemicals are in very close proximity to hundreds of people each day. Thus, in hospital spillage of blood, body fluids or chemicals can occur at any time due to broken or faulty equipment or human error. Any such spill poses risk to the staff, visitors and patients who are extremely susceptible to infection. Occupational spill exposure continues to be the major worldwide public health problem, despite advances in our understanding and control of these infections.

Objectives:

1. To assess knowledge regarding hospital spill exposure management among staff nurses.

2. To identify the knowledge of staff nurses regarding hospital spill exposure management.

3.To determine the correlation between level of knowledge and effect of demonstration among staff nurses regarding hospital spill exposure management.

Material and method: Quantitative quasi experimental one group pre and post-test. Setting of the study: Hospital staff nurses.

Result: From the findings of the present study, it can be concluded that the demonstration programme regarding knowledge on spill management among staff nurses was effective to improve the level of knowledge on spill management.

Conclusion: From the findings of the present study, it can be concluded that the demonstration programme regarding knowledge on spill management among staff nurses was effective to improve the level of knowledge on spill management.