Cryotherapy and stimulation both having post injury positive effect in treatment to reduce pain inflammation edema as well as gaining the strength via activation of inhibited muscles. There may have some tolerance issue with patient while using stimulation ( NMES) which can be reduced by prior use of ice over the muscle, infact short duration of cryo application may increase the threshold to tolerate higher stimulation to produce powerful contraction. Cryotherapy and stimulation widely used after knee injury to activate quadriceps after reflex inhibition achieved due to pain, and inflammation. Studies proved that cryotherapy can used in acute condition whereas stimulation is used in chronic condition for gaining strength. Cryotherapy also used after every soft tissue injury specially in sports injuries but some studies support the use of cryotherapy for 15 min reduce dynamic postural stability after lower limb injury.

Keywords: Cryotherapy; Inflamation; Cryo Stimulation.