Aim:  The aim of the study was to find out the efficacy of wrist manipulation and phonophoresis, flexibility and endurance training on pain and grip strength in lateral epicondylitis patients. Methods: A total of 30 patients having lateral epicondylitis, included both male and female, age ranges from 25 to 50 years were selected as subjects and they were further divided into 2 groups. Each group comprising of 15 subjects (male=7; female=8). Group A (Control) received phonophoresis, flexibility and endurance training and Group B (Experimental) received wrist manipulation along with phonophoresis, flexibility and endurance training for 3 days per week. For both groups total duration of treatment was for 4 weeks. Numeric Pain Rating Scale and Grip Strength were used as pre and post outcome measures. Results: Result of the study suggests that there was improvement in the mean value of Numeric Pain Rating Scale and Grip Strength after treatment in both groups. But the treatment was statically more significant in Experimental group than Control group. Conclusion: It was concluded that the patients of lateral epicondylitis show more improvement when receiving wrist manipulation along with phonophoresis flexibility and endurance training.