Context: Osteoarthritis is a non-inflammatory degenerative disorder of joints characterized by progressive deterioration of the articular cartilage and formation of new bone i.e., osteophytes. As knee OA is very common in India especially in females and if we are able to correlate balance, physical function and ADL’S with subtalar angle deviation, a better physiotherapy protocol can be designed. Aims: The main objective of this study was to investigate the correlation of balance, physical function and ADL’S with subtalar varus angle (STVA) in females with unilateral medial compartment knee OA. Settings and Design: Correlational study design. Methods and Material: 30 females with stage 2/3 unilateral medial compartment knee OA, aged in between 40-65 years participated in the study. Assessments were made by the stair climbing test, timed up and go test, WOMAC scale, and goniometric assessment for subtalar varus angle. Statistical analysis used: Statistical analysis was done with the help of SPSS software by calculating the Pearson’s correlation coefficient. Level of significance accepted is p < 0.05. Results: The Pearson’s correlation coefficient between STVA and physical function is r=0.3830, between STVA and balance is r=0.0632 and between STVA and ADL’S r=0.1438. Conclusions: There is a low correlation present in between STVA, physical function, balance and the ADL’S.