Objective: To compare the effectiveness of modified constraint induced movement therapy versus mirror therapy  along with conventional therapy on hand rehabilitation in patients with acute and sub-acute stroke. Methodology Design: Comparative study Setting: OPD and IPD of SMIH Patel Nagar, Dehradun (UK). Participants: 30 acute and sub-acute stroke patients were included in this study and randomly divided into  2 groups 15 in each i.e. mCIMT along with conventional therapy(group A) and MT along with conventional  therapy(group B). Intervention: 30 subjects who were diagnosed with stroke onset <6 week were selected according to the inclusion  criteria. Hand function and functional ability was evaluated with the help of w/h FMUE and ARAT scores. The  subjects perform exercises in each group along with conventional therapy for 45 minutes 6 days per week for a  consecutive 4 weeks. Along with daily therapy session constraining of less affected upper extremity with a mitt was  done in group A patients. The post intervention data was compared with pre intervention data and improvement  in the hand function was measured. Outcome Measures: w/h Fugl-Meyer Upper Extremity Scale (sub scale B & C of FMUE) Action Research Arm Test (ARAT). Result: Data was analyzed by using paired t- test. Pre and post score were taken via w/h FMUE and ARAT. P  value <0.05. Conclusion: Modified constraint induced movement therapy and Mirror therapy along with conventional  therapy both showed improvement in hand functions on acute and sub-acute stroke patient. But Modified constraint  induced movement therapy along with conventional therapy showed more improvement in reaching forward,  grasping, manipulating objects and also improves other fine motor functions of the hand after 4 weeks of therapy. Keywords: Modified constraint induced movement therapy; Mirror therapy; Acute & sub-acute stroke; w/h  FMUE; Action Research Arm Test; Hemiparesis.