Quasi-Experimental study was carried out to evaluate the effectiveness of educational session on premenstrual syndrome among reproductive age women in selected rural areas, Tirupati, Andhra Pradesh.  Data was collected from 50 women living in Peruru Village, Tirupati.  Significance findings in the pretest revealed that a majority (84%) has inadequate knowledge and (10%) has moderate knowledge and (6%) had adequate knowledge on various aspects of PMS. After providing education significant knowledge was gained which reveals 82% of women gained adequate knowledge while 14% of women gained moderate knowledge and 4% of women gained inadequate knowledge on PMS.  The t-value is 28.706, which is statistically significant at 0.01 levels.  The conclusion suggests that the education when imparted to women on premenstrual syndrome can bring improvement in their knowledge and lead to the adoption of preventive practices against premenstrual syndrome.