Introduction: There are 9 COVID-19 vaccine candidates in different phases of development in India, of these 3 are in pre-clinical phase whereas 6 are under clinical trials. Two of them are used in emergency basis, which include Covaxin by Bharat Biotech and Covishield by Serum Institute of India. Misbelieves: There are some misbelieves regarding use of these vaccination in terms of side effects and effectiveness. Adverse Events Following Immunization: These are the symptoms recognized after immunization in some individuals. It can be minor, severe or serious. AEFI prevention and management: AEFI can be prevented and managed by careful monitoring and symptomatic treatment with detailed history collection.