Background: Peptic ulcer is one of the most common malady that affects the mankind in South India. Though lot of work had been done on the etiology of this condition, one specific etiological agent cannot be incriminated in the causation of this particular disease especially in our part of country. Peptic ulcer may produce one of the three main complications: haemorrhage, perforation or obstruction. In our study, we will be restricted to find out the magnitude of complications of peptic ulcer with special reference to the failure of conservative treatment, complications due to irregular treatment, etiological factors and various surgical treatment modalities.

Materials and Methods: The patients admitted to J.J.M. Medical College Davangere with primary diagnosis ofcomplications of peptic ulcer disease with complication and who underwent surgical management for the above was taken for this prospective study from June 2009 to June 2011. A minimum of 50 cases after applying inclusion and exclusion criteria were selected for this study and allocated alternatively to each of the clinical study. A
pretested proforma was used to collect relevant information from all the selected patients.

Results: In this prospective study of 50 cases, 35 cases (70%) of perforation, 2 cases (4%) of bleeding and 13 cases (26%) of gastric outlet obstruction were documented. Study revealed male predominance, mainly in the 3rd and 4thdecade with male to female ratio of 7.3:1. 32 (64%) patients of the study group with previous history of peptic ulcer disease, 12.5% among them who were on regular conservative treatment and the remaining 87.5% of patients taking irregular treatment came with the subsequent complications.

Conclusion: In the present era of potent PPI and anti H. Pylori treatment, medical
treatment plays a vital and pivotal role in treating expectantly majority of patients with peptic ulcer disease. Though revolutionary advances have come into lime light in the conservative management of the disease, surgical management is mandatory for patients with refractory and complicated peptic ulcer disease.

Keywords: Perforated Peptic Ulcer; Bleeding Peptic Ulcer; Gastric Outlet Obstruction; Nsaids; Smoking; H.Pylori; Proton Pump Inhibitors.