Appendicitis remains as the disease encountered by practising surgeon. It is the most common urgent or emergent general surgical operation performed. This remains as sole reason for 300,000 hospitalizations yearly [1] upto fourteen different organisms are found in patients with perforated appendicitis. E.coli and Bacteroides frigilis are the common organisms encounterd in perforated appendicitis [2]. Our study is a prospective study which included 150 patients which were made into two groups one study and one control group where single dose and multiple doses of third generation cephalosporin were given and wound grading was done with southhamtom score. In our study with evidences available it is clear that extra doses of cefaperazone and sulbactam confer no extra advantage, as single dose can be given with much ease and offers reduced financial burden for the patient. The hospitals should make routine antibiotic protocols and keep changing it time to time in order to reduce antibiotic reistance in the current era of super bugs it is the duty of the surgeon to comply with the current standards of antibiotic care in order to reduce the complications regarding the drug resistance and complication regarding the wound infection.

Keywords: Uncomplicated Appendicitis; Third Generation Cephalosporin; Single Dose; Multiple Dose.