Background: Necrotizing soft tissue infections are frequently associated with a fulminant presentation and fatal outcomes. A side from critical care and antibiotic therapy, aggressive surgical treatment is essential for the treatment of necrotizing fasciitis. The purpose of this study was to see if post-operative procalcitonin, lactate dehydrogenase, albumin, and culture sensitivity could be used to predict successful surgical intervention.

Methods: The study group consisted of 92 patients treated with clinical signs of sepsis caused by a necrotizing soft tissue infection. All patients received radical surgical treatment, and S.PCT, S.LDH, Albumin and wound culture and sensitivity were sent on POD3.

Results: Out of 92 patients’ mortality was seen in 11 patients and amputation was done in 6 patients. The biochemical markers which were included in the study showed significant results (p<0.01) * that is serum procalcitonin and serum LDH were elevated and s. albumin was low in all patients who are died and amputated except in one patient. There was no significant in the microbial flora and the outcome of the patient.

Conclusions: The biochemical markers PCT, LDH, Albumin following major surgical procedures for necrotizing soft tissue infections represents a valuable clinical tool indicating successful surgical eradication of the infectious focus.