Aim of this case report is to assess the role of cyclical negative pressure wound therapy (CNPWT) in management of skin graft donor site healing. Clinical examination of the donor site before and after the use of cyclical negative pressure wound therapy (CNPWT) was done. Cyclical negative pressure wound therapy (CNPWT) is effective in healing of donor site wound. Cyclical negative pressure wound therapy (CNPWT) may be used in donor site healing.