Schizophrenia is a severe mental illness, which causes significant morbidity and disability. Patients suffering from schizophrenia have a relatively shorter life span in comparison to their healthy counterparts. It follows chronic, waxing-waning course and needs long term treatment. Co-morbidities are common in patients with schizophrenia, may it be co-morbidities involving physical or mental health. Presence of co-morbidities compromises quality of life and increases the disability as well as burden of care. Every patient suffering from schizophrenia should be evaluated  and treated for their co-morbidities adequately to have a better quality of life.