Onset of chronic illness requires adjustment in lifestyle in prolonging life and improves the quality of life. Patients with end stage renal disease are faced with complicated and demanding treatment regimen that include dietary and fluid restrictions and medication schedule and regular dialysis they can lead a near normal life provided that they have the good quality of life. Hence the investigator assessed the Quality of life of patients with chronic renal failure on regular hemodialysis in the different aspects of physical, physiological, psychological, social and spiritual, to assess the overall level of quality of life, and to associate the level of quality of life of chronic renal failure patients with selected demographic variables. A descriptive design was chosen to assess the quality of life of patients with chronic renal failure with the help of a standardized questionnaire, data was collected and analyzed using inferential statistics. The findings revealed that in physiological aspects 58% patients were in poor quality of life, in physical status 56% patients were in moderate quality of life, in psychological aspects 58% patients were in moderate quality of life, in social aspects 80% patients were in moderate quality of life, and in spiritual aspects 78% patients were in moderate quality of life. The study concluded that 92% of patients were having moderate quality of life, only 4% of patients were having poor quality of life and 4% of patients were having good quality of life.