Introduction: The leiomyomas are commest benign tumors in utreus. It is composed of proliferation of smooth muscle cells and fibrous connective tissue. The various interactions of sex steroid hormones and local growth hormones are important for development of these tumors. Also genetic cause related to mutations in the normal myometrium is considered as the other etiological factor. Aims and Obectives: To study and analyse various histopathological patterns of uterine leiomyomas in surgically excised hysterectomy specimens. Material and Methods: The present study was done at the Department of Pathology, DY Patil, Medical College, Kolhapur, Maharashtra, India, for the period of three years from Jan 2016 to December 2018. Results: A total of 116 surgically excised hysterectomy specimens which were clinically and radiologically suspected of uterine leiomyomas were studied. The maximum numbers of patients in this study were between 41–50 years (46.5%). The clinical sign and symptoms of menorrhagia being the most common indication for hysterectomy. The intramural location was common site of leiomyomas in this study. Conclusion: We observed in female reproductive tract uterine leiomyomas are the most common tumors. Most of the cases were asymptomatic. The intramural location was common site of leiomyomas in this study.

Keywords: Hysterectomy; Leiomyoma; Menorrhagia