Background: Neonatal sepsis is one of the important causes of morbidity and mortality in the neonatal period. Objectives: To analyse the hematological findings according to Rodwells hematological scoring system and correlation with blood culture. Materials and methods: A Total of 120 neonates were included in the study. Blood samples from 120 neonates were subjected to blood culture and Hematological scoring system (HSS). They were divided in to 3 groups i.e group 1 (proven sepsis - 32), group 2 (probable sepsis - 56) and group 3 (Normal infant - 32). Results: Out of 120 infants, 32 had positive blood culture. Majority (66.6%) were preterm. Male to female ratio was 1.7:1. Out of 32 sepsis cases, 27 (84.3%) had predominant score was 5 >. Maximum number of cases 31 (55.31%)) showed score with 3-4 in probable sepsis group. Association of hematological parameters and scores was found to be statistically significant (p<0.05). Majority of parameters found to have high sensitivity while platelet count and Total Neutrophils count (TNC) had high specificity. Combination of hematological tests found to have high sensitivity and specificity when compared to single hematological test. Conclusion: Hematological scoring system is easy, cheap and cost effective screening tool for early diagnosis of neonatal sepsis. 

Keywords: Hematological Scoring System; Hematological Parameters; Culture; Neonatal Sepsis.