Background and objectives: Ophthalmic pathology being a sub-branch of surgical pathology, deals with the characterization and diagnosis of ocular diseases. In India, not many studies on histopathological study of ocular lesions have been published. Keeping this in view, histopathological study of ocular lesions is undertaken. 

Aims: To study the histopathological spectrum of ocular lesions received in Department of Pathology, K.R. Hospital, Mysore.

Materials and methods: All excised ocular specimens received in Department of Pathology, Mysore Medical College and Research Institute, Mysore during the study period from December 2012 to May 2014 were included in the present study. A total of 100 biopsies and whole specimen of tumours were obtained from various wards of Department of Ophthalmology. Sample for Histopathological diagnosis were obtained either through incisional or excisional biopsy.

Results: A total of 100 ocular lesions from 100 patients were analysed. 51 were women and 49 were men and the age of the patients ranged from 1 year to 73 years. Eyelid (41%) was the most commonly involved site. Clinical diagnosis was consistent with histopathological diagnosis in 69% of cases. Among eyelid lesions, incidence of dermoid cyst was the highest, while in conjunctival lesions, Bowen’s disease was highest followed by other lesions. A clinico-pathological diagnosis of malignant ophthalmic tumors was made in 11% of cases, while 83% cases were benign lesions and 6% were premalignant in nature. 

Conclusion: Out of 100 cases of ocular lesions, eyelid (41%) was the most common site affected and conjunctiva was the second commonest site. Ocular lesions showed no particular sex predilection. Clinico-histopathological correlation was seen in 69% of cases. Precise diagnosis and characterization of all excised ocular lesions by histopathological examination is very important to the clinicians for the further appropriate management of patients.

Keywords: Ocular Lesions; Eyelid; Conjunctiva; Dermoid Cyst.