Safety of Blood and Blood components transfusion begins with healthy donors. Deferral of Blood donation is because of both temporary and permanent reasons. Hence personnel  who are willing to donate blood are not able to donate blood successfully either permanently or temporarily.

Aim: To evaluate the various reasons for blood donor deferral among blood donors in a tertiary care teaching hospital, Blood bank unit.

Material & Methods: A retrospective study from January 2014 to December 2017 was done. An analysis of records of the donors were reviewed in order to find out the rate and causes of pre donation deferral both in male and female in Blood Bank unit.

Results: During this four year period, 7849 donors registered to donate whole blood and blood components and 561 were deferred. The deferral rate was 7.14 %. Among 561 deferral blood donors, 472(84.1%) were male and 89 (15.8%) were female. Female registered donors were less as compared to male. The reasons for deferral were grouped as temporary and permanent. The reasons of temporary and permanent deferral constituted 93.9% and 7.1% respectively. The three most common reasons for temporary deferral were anaemia, under age and low body weight. The permanent reasons were hepatitis, diabetes and respiratory diseases. As per available findings in the literature and findings from our study remain same.

Keywords: Blood Donor; Deferral; Permanent Deferral; Temporary Deferral.