Introduction: Renal tumors comprise a diverse spectrum of neoplastic lesions with patterns that are relatively distinct for children and adults. Radical nephrectomy is indicated to treat different malignant neoplastic conditions of the kidney. Nephrectomy remains the standard of care for patients with a suspected renal mass. Accurate pathological evaluation of renal neoplasms is essential for sub typing, proper staging and assisting in further treatment protocols.

Methodology: The study was prospective and included 40 nephrectomy specimens over a period of 2 years. The gross morphology and the microscopic features were studied.

Results: In the present study, a total of 40 cases of nephrectomy specimens were studied. Of the 40 cases, 15 were neoplastic lesions (37.5%).

Conclusion: It is mandatory for every nephrectomy specimen to be subjected, to a detailed Histopathological examination, for a clinico-pathological correlation to ensure proper management. The clinical outcomes of various histologic subtypes are different, validating for accurate sub typing of renal neoplasms in clinical practice.

Keywords: Nephrectomy; Renal Cell Carcinoma; Sarcomatoid; Wilms Tumor.