Introduction: Thyroid lesions are common in surgical practice and are observed in 4- 7% of the population. Fine needle aspiration cytology [FNAC] is a highly accurate, economical, safe, minimally invasive and rapid , pre-operative diagnostic modality in detecting thyroid lesions. The use of FNAC as the first line of investigation in thyroid lesions has reduced the number of unnecessary thyroidectomy procedures.

Objectives: The present study was undertaken to correlate the fine needle aspiration cytology [FNAC] findings with histopathology wherever possible. Methods: In the present study, 95 cases of thyroid FNACwhich were subsequently
followed by excision biopsy has been statistically analyzed and cyto-histopathological correlation has been interpreted.

Results: Out of 95 cases studied, with cyto-histopathological correlation, the majority of lesions were non- neoplastic. The accuracy was found to be 93%, sensitivity 71.45%, and specificity 100%.

Conclusion: FNAC can be used as a baseline investigation in patients with thyroid lesions and has high accuracy in detecting and differentiating malignant lesions from the benign.

Keywords: FNAC; Accuracy; Sensitivity; Specificity; Cyto-histopathological Correlation.