Introduction: The prostatic cancer is the second most common cause of cancer death in men.

Aim: To elaborate the study of mucin histochemistry in prostatic lesions and establish theutility of Mucin Stains in distinguishing benign lesions from in situ and malignant lesions.

Materials and methods: In the retrospective and prospective study. Cases were admitted and biopsied who underwent prostatic biopsies and surgeries due to various prostatic pathologies. Biopsy specimen paraffin blocks of the tissue were obtained and fresh sections were made with a thickness of six microns on a rotary microtome. All the sections were stained with Hematoxylin and Eosin.

Results: A five year combined retrospective and prospective study from 1 st January 2012 to 31 st October 2016, revealed a total of 347 prostate biopsies. The total number of biopsy specimens received during the above five year period were 13338, and the prostate biopsies accounted for an overall proportion of 2.6 %. 89% of cases in study are malignant and 21% are benign.

Conclusion: Mucin histochemistry evaluation is a simple, reliable and economical technique to confirm the presence of malignancy in suspicious lesions.

Keywords: Mucin Histochemistry; Prostate Lesions; Alcian Blue-PAS Stain.