Introduction: Papillary breast lesions are a group of lesions that are characterized by presence of papillae supported by fibrovascular cores lined by epithelial cells with or without myoepithelial cell layer. Aims: This study was conducted to analyse the clinicopathological characteristics of papillary lesions of the breast. Materials and Methods: A retrospective and prospective analysis of 12 cases of papillary lesions of breast received over a period of 2 years was done. The patient’s clinical details were collected from medical archives and the histopathological findings were reviewed. The lesions were classified into benign, atypical and malignant categories. Results: During the study period, 12 cases of papillary lesions of breast were reviewed. The mean age was 43 years. The central quadrant was the most common location (66.6%). The most common presenting complaint was lump (75% cases), more commonly as solitary lump (83.3%) rather than multifocal disease (16.7%). Benign papillary lesions (58.3%) were more common than the malignant lesions (41.7%). The most common papillary lesion was intraductal papilloma (50% of the cases), followed by invasive micropapillary carcinoma and intracystic papillary carcinoma constituting 25% and 16.7% cases respectively. Conclusion: Diagnosis of papillary lesions is challenging and its classification includes different entities that have specific diagnostic criteria. Due to their heterozygosity in morphology with benign, atypical and malignant subtypes, morphological features such as type of fibrovascular core and continuity of myoepithelial layer along with immunohistochemical stains for myoepithelial cells should be considered for accurate diagnosis and proper management.

Keywords: Fibro Vascular Core; Myoepithelial; Papillary Lesions.