Background: Liver diseases cause significant morbidity and mortality in both pregnant women and infant. Early diagnosis and timely intervention will help us to achieve reduction in maternal and infant mortality. Aim: To study histopathological changes in liver in cases of maternal deaths and to correlate with biochemical profiles. Material and Methods: A retrospective analysis of 101 cases of maternal deaths received in the year 2016 were studied. The histopathological changes in liver were reviewed and were correlated with liver function test if available. A total of 99 cases were available for study. A Result: Liver disease related to pregnancy was seen in 31% of cases, with pre eclampsia/ eclampsia leading the list. In 3% of cases liver disease developed concurrently with pregnancy, while in single case pregnancy was seen in pre existing liver disease. Incidental findings were seen in 35% of cases, while in 29% of cases no changes were seen. Conclusion: Autopsy helps us to understand the pathogenesis and presentation of liver pathology in maternal deaths. The study helps us to diagnose liver diseases in pregnancy with varied presentation in early stage. This will help in achieving our national goal of reducing maternal and foetal.

Keywords: Pre eclampsia/Eclampsia.