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Indian Journal of Pathology: Research and Practice

Volume  5, Issue 1, Jan-Apr 2016, Pages 9-13
 

Original Article

Comparison of Clinico-Pathological Features of Primary Esophagus Malignant Neoplasms with Gastrointestinal Malignant Neoplasms

N. Rajesh Kumar*, P.M. Subramanium**

*Associate Professor **Professor, Department of Pathology, Annapoorana Medical College and Hospital, NH 47, Sankari road, Serangapadi, Salem, India.

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DOI: DOI : https://dx.doi.org/10.21088/ijprp.2278.148X.5116.1

Abstract

 Objectives: The aim of the study is to determine the   clinico-pathological features of primary esophageal l malignant   tumors and to compare with primary gastrointestinal malignancies. Materials and methods: 45 patients with primary   esophageal  malignant   tumors  diagnosed over a 5 year period  were studied clinically and histopathologically,  they were classified using the  WHO classification and  compared with  300 primary gastrointestinal tumors and the previous studies. Result: 45 patients (15% ) were esophageal  malignancies arising out of 300 primary gastrointestinal malignancies, with a male to female  ratio of  3.5:1. Majority  were males, majority were  non vegetarians and  most of the males were alcoholics and smokers. The youngest patient affected is 20 years old and the oldest patient is 78   years old with mean age of 52.17 and median age of 53 years. Tumor more common in the  sixth and  seventh  decade of life.In esophagus, the presenting symptoms in the decreasing order of frequency were dysphagia, weight loss, hematemesis  and abdominal pain. Malignant tumors were more common in lower one third with 25 cases (55.55%) followed by frequency in middle and upper one third of esophagus with a male preponderance. Ulcerative type of lesion was the most common gross presentation in  55.5% of the tumors followed by exophytic and infiltrative pattern.  The commonest malignant tumor of esophagus was squamous cell carcinoma constituting  71.8%, and rest  include adenocarcinomas, poorly differentiated carcinomas and a single case of adenosquamous carcinoma. Conclusion: Primary  esophageal  malignancy   constitute  about 15%  of all gastrointestinal malignancies, males commonly affected (3.5 :1) and more common in alcoholics and non vegetarians. dysphagia, weight loss, hematemesis and abdominal pain was the most common clinical presentations,  more common in lower one third with 25 cases (55.55%). Ulcerative type of lesion was the most common gross presentation in 55.5% of the tumors, Histologically 71.8% were sqamous cell carcinoma and few cased of  adenocarcinomas, poorly differentiated carcinomas and a single case of adenosquamous carcinoma.

Keywords: Primary Esophageal Malignancy; Gastrointestinal Neoplasms.

Corresponding Author : N. Rajesh Kumar*