Background and Objectives: The technique of percutaneous renal biopsies is the cornerstone for our understanding of diseases of the kidney. Studies done on percutaneous gun biopsies performed under realtime ultrasound guidance have given higher diagnostic yield with fewer complications. The present study aims the spectrum of glomerular diseases which require renal biopsy and to correlate the pathological findings of glomerular diseases with clinical and laboratory parameters. Materials and Methods: A total of 75 cases were studied over a period between 31072005 and 31072008 which includes 1 year retrospective and 2 years prospective study. The renal biopsy was performed by 18 Gauge Bard’s ‘bioptic gun’ under real time ultra sound guidance and a renal tissue ranging from 23cm was obtained. Sections were studied with Haematoxylin and Eosin, Special stains like Periodic Schiff Stain, Silver and Congored. Immunofluorescence was done where ever necessary. Results: The study showed that among 75 cases the majority of biopsies were of primary glomerular diseases in which focal segmental glomerulosclerosis was most common accounting for (25.00%) of cases followed by mesangioproliferative glomerulonephritis (22.03%) of cases. Among the secondary glomerular diseases renal amyloidosis (55.00%) was found to be more common in patients who presented with nephrotic syndrome and maximum cases were of secondary amyloidosis in which tuberculosis and chronic respiratory infections like bronchiectasis were common. Conclusion: Focal segmental glomerulosclerosis, mesangioproliferatve glomerulonephritis and amyloidosis of kidney were found to be common in the present study.