Leiomyoma with bizarre nuclei (LBN) is an uncommon variant of uterine smooth muscle neoplasm. A 52 year female presented with complained of intermittent pelvic pain, abnormal uterine bleeding, and abdominal discomfort of 6 month duration. On ultrasonic evaluation showed well defined uterine masses suggestive of leiomyomas. The systemic examinations were normal. On histopathologycal finding reported as uterine leiomyoma with bizarre nuclei. Patient responded well to treatment. On follow up there was no evidence of recurrence. We are presenting this uncommon case of leiomyoma with bizarre nuclei for its clinical, radiological and histopathological findings. On histopathological findings this tumor should be properly differentiated form various uterine spindle cell tumors with nuclear atypia for better management of patients.