Benign prostatic hyperplasia (BPH) and adenocarcinoma are common diseases that account for considerablemorbidity and mortality in the aging population. Prostatic intraepithelial neoplasia (PIN) refers to the preinvasive end of the continuum of cellular proliferations within the lining of the prostatic ducts, ductules and acini, with cytological changes mimicking cancer.Prostate cancer (PCa) is the most prevalent cancer found in men above the age of fifty years. Adenocarcinoma of the prostate range from well-differentiated gland forming cancers to poorly
differentiated tumors.

Aim: To evaluate the histopathological variants of prostatic lesions in prostatectomy specimens.

Materials and Methods: A prospective study was done to evaluate the various histological lesions in prostate specimens received in our institution. Statistical Analysis Used: The data collected was entered in MS Excel spreadsheet and analysed using SPSS version 20.
Results: Out of 90 prostate specimens studied, commonest pathology encountered was benign lesions constituting 94.5% and malignant lesions were 5.5%. Out of 84 cases of benign lesions, 51 cases (64.28%) were diagnosed as nodular hyperplasia only and NH was associated with 6 cases of basal cell hyperplasia (7.14%), 5 cases of squamous metaplasias (5.95%), 2 cases of transitional metaplasia (2.38%), and 20 cases (23.80%) of prostatitis. Diagnosis of
prostatic carcinoma was made in 5 cases (5.5%).

Conclusion: Histologically, all the malignant lesions encountered were adenocarcinoma of prostate. The commonest pattern seen was acinar followed by arrangement of tumor cells in cords, sheets and cribriform pattern.
Keywords: Benign prostatic hyperplasia (BPH); Prostatic intraepithelial neoplasia (PIN); Prostatic adenocarcinoma.